{"id":71358,"date":"2017-01-10T13:21:43","date_gmt":"2017-01-10T13:21:43","guid":{"rendered":"http:\/\/icia.ro\/?p=71358"},"modified":"2017-01-20T14:24:25","modified_gmt":"2017-01-20T14:24:25","slug":"28-markeri-endofenotipici-si-susceptibilitatea-genetica-schizofrenie-schizofenotip","status":"publish","type":"post","link":"https:\/\/icia.ro\/en\/2017\/01\/10\/28-markeri-endofenotipici-si-susceptibilitatea-genetica-schizofrenie-schizofenotip\/","title":{"rendered":"Endophenotypic markers and genetic susceptibility in schizophrenia , SCHIZOFENOTIP"},"content":{"rendered":"

Objectives:
\nperforming a comprehensive psychological, genetical and biochemical evaluation of schizophrenic patients and to evaluate the effects of enzymatic cofactors supplemented treatment on some of these parameters.<\/p>\n

<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
OBJECTIVES<\/b><\/td>\n\n
    \n
  • performing a comprehensive psychological, genetical and biochemical evaluation of schizophrenic patients and to evaluate the effects of enzymatic cofactors supplemented treatment on some of these parameters. Thus, the project was designed as a well-defined clinical study, conducted on a distinct cathegory of psychiatric patients, aimed to fully describe the relevance of a group of biological parameters for the ethiopathogenesis of this disease: plasma homocysteine profile, corelated with human serum paraoxonase 1 activities and oxidative stress markers, several genetic polymorphisms, several life-style factors and a number of endophenotipical markers (e.g. working memory, emotional discrimination capacity etc.)<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
<\/td>\n<\/tr>\n
DESCRIPTION<\/b><\/td>\nThe objective of the project Schizophenotyp is to realize a clinical study orientate on the patients with specific cerebral diseases, with referral to schizophrenia. The objective of clinical study is the complete characterization of the factors involved in the schizophrenia pathology: the plasmatic homocystein profile, the activity of paraoxonazei 1 and the oxidative stress; the characterization of the genetic polymorphism and associating this to the life style (stress factors, smoking, alcohol, a sedentary life, unhealthy alimentation. At this moment there is a lot of information about the increasing level of oxidative stress in the schizophrenia pathology, on the other hand there isn\u2019t a lot of information about the producing mechanism and its implications. A correct diet can prevent the early development of a neuro-psychic pathology that involves reactive species of oxygen (ROS) or can protect a patient that has the early stage of the diseases. In the daily diet is necessary to have folic acid and B12 vitamin for the good function of MTHFR and MS enzymes involved in the homocystein metabolism.<\/td>\n<\/tr>\n
<\/td>\n<\/tr>\n
RESULTS ESTIMATED<\/b><\/td>\n\n
    \n
  • Developing new, supplementary therapies, with products from the class of the enzymatic cofactors, having a predictable impact in improving the evolution and prevention of decompensation of the schizophrenic patients;<\/li>\n
  • Database;<\/li>\n
  • Centralised informatic system;<\/li>\n
  • Questionnaires;<\/li>\n
  • Protocol;<\/li>\n
  • Promotional materials;<\/li>\n
  • Scientific papers.<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
<\/td>\n<\/tr>\n
RESULTS OBTAINED<\/b><\/td>\n\n

Stage I
\nPeriod: Oct. – Dec. 2005
\nStudy of the importance of endophenotypic markers and genetic susceptibility in schizophrenia<\/strong><\/p>\n

The evaluation of, forms elaboration for the patient\u2019s monitorising and the draw out the specification of data base.<\/p>\n

 <\/p>\n

Stage II
\nPeriod: Dec. 2005-Oct. 2006
\nRealization of patient lot and the initiation of treatment with enzymatic co-factors<\/strong><\/p>\n

Prelucration of biological tests.
\nRealization of data base.<\/p>\n

Stage III
\nPeriod: Oct. 2006-Sep. 2007
\nAdministration of the treatment, genetic evaluation and patient re-evaluation<\/strong><\/p>\n

The final evaluation of patients.
\nThe implementation of the results in the data bases.<\/p>\n

Stage IV
\nPeriod: Sep. 2007-Nov. 2007
\nDissemination of results<\/strong><\/p>\n

The elaboration of articles and communications.
\nWeb page, CD presentation of results.
\nOrganization of an workshop.<\/p>\n<\/td>\n<\/tr>\n

<\/td>\n<\/tr>\n
Other Informations<\/b><\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/tr>\n
<\/td>\nAttached documents:<\/b>
\n\"\"\u00a0ICP MS blood<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/p>","protected":false},"excerpt":{"rendered":"

Sorry, this entry is only available in Romanian.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[24],"tags":[],"acf":[],"yoast_head":"\nEndophenotypic markers and genetic susceptibility in schizophrenia , SCHIZOFENOTIP - INCDO INOE 2000 ICIA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/icia.ro\/2017\/01\/10\/28-markeri-endofenotipici-si-susceptibilitatea-genetica-schizofrenie-schizofenotip\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Endophenotypic markers and genetic susceptibility in schizophrenia , SCHIZOFENOTIP - INCDO INOE 2000 ICIA\" \/>\n<meta property=\"og:description\" content=\"Sorry, this entry is only available in Romanian.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/icia.ro\/2017\/01\/10\/28-markeri-endofenotipici-si-susceptibilitatea-genetica-schizofrenie-schizofenotip\/\" \/>\n<meta property=\"og:site_name\" content=\"INCDO INOE 2000 ICIA\" \/>\n<meta property=\"article:published_time\" content=\"2017-01-10T13:21:43+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2017-01-20T14:24:25+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/old.icia.ro\/Documents_Files\/doc_icons\/PDF.gif\" \/>\n<meta name=\"author\" content=\"icia\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"icia\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/icia.ro\/2017\/01\/10\/28-markeri-endofenotipici-si-susceptibilitatea-genetica-schizofrenie-schizofenotip\/\",\"url\":\"https:\/\/icia.ro\/2017\/01\/10\/28-markeri-endofenotipici-si-susceptibilitatea-genetica-schizofrenie-schizofenotip\/\",\"name\":\"Endophenotypic markers and genetic susceptibility in schizophrenia , SCHIZOFENOTIP - 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