by icia icia

Pharmacogenomic impact of the determination of VKORC1 and CYP2C9 genes over the efficacy, safety and costs of the anticoagulant treatment, TROMBOGEN

Objectives:
to investigate the pharmacogenomic status of the patients, from both geno- andphenotypic point of view;
to reveal the polymorphism of the CYP2C9 and VKORC1 genes, and alsoof the genes involved in the thrombophilia phenomenon (Factor V Leiden, FII G20210A, PAI-1 4G/5G, MTHFR C677T and A1298C) and the possible relationship between the presence of these polymorphisms and the response to acenocumarol treatment;

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by icia icia

Development of spectrometric methods for identifying and tracking sources and pollution potential using analysis of trace rare earth,

Objectives:
The purpose of the project is the development and validation of complex analytical methods that can provide very useful information on pollution sources and their potential of pollution (especially tailings and ponds), methods based on mass spectrometry with inductively coupled plasma (ICP-MS), for determination of isotopic ratios and rare earth, and X-ray diffraction (XRD) to determine the mineralogy.

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by icia icia

Multi-element analysis of apples, pears and corresponding leaves and blossom leaves as indicators for yield and sites of origin, as well as contributions to human nutrition, APLON

Objectives:
The polyphenols and metals from fruits have an important role in maintaining a good function of the organism. The benefic or negative role of these compounds on the organism is given by the concentration level in which they are found in fruits. The concentration level is strongly influenced by the cultivation area, grower, the pollution level in the area, environmental factors and other less important factors.

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by icia icia

Assessment of metals bioavailability in soils and sediments using Diffusive Gradients in Thin-films technique, chemical extractions and biological methods , BIOMET

Objectives:
Studies have demonstrated that biological effects are not related to the total concentration of a contaminant in the environment. Biological responses of organisms have been shown to be related to the concentration of labile metal species in environment and, at international level is expressed the need to evaluate risk of exposure to toxic metals in terms of their bioavailability.

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